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Cannabidiol (CBD) for the management of cannabis withdrawal: a phase II proof of concept open label study

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Honorary Professor
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Dr Nicole Clement
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Ms Izabella Pokorski
Research Officer
Project Main Description: 

This is a feasibility study to test the effectiveness of cannabidiol (CBD) for alleviating cannabis withdrawal symptoms in a 6 night inpatient detoxification program.

Project Collaborators: External: 

Dr Nghi Phung
Western Sydney Local Health District

Prof Martin Weltman
Nepean Hospital


To assess the effectiveness of CBD in reducing cannabis withdrawal symptoms.

Design and Method: 

This is a single subject repeated measures design, whereby one subject is assessed at baseline/time 1, given the intervention (CBD) and assessed again at time 2 (Day 3 of detox) and time 3 (day 7 of detox) and time 4 (28 days post admission follow-up) in addition to daily Cannabis Withdrawal Scale completion. This process is then repeated with 7 additional participants in order to replicate the findings. The intervention consists of 300mg of CBD on day 1, 300mg of CBD morning and night on days 2-5 and 300mg of CBD on day 6 for n=5 and 600mg BD for a further 3 participants. The aim of the assessment is to measure the safety and acceptability of the medication in reducing self-reported withdrawal symptoms.


The study has been completed. 


The medication was found to be acceptable and free of adverse events even at the dose of 1200mg/day.


Presentation at national and international conferences. The findings are currently being prepared for peer reviewed journal publication.


These data provide support for funding submissions for a double blind randomised controlled trial.

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