Cytisine versus varEnicline for Smoking cesSATion – The CESSATE study

image - CESSATE Image 3
Drug Type:
Project Main Description: 

CESSATE - A study helping people to stop smoking.

The majority of smokers want to stop smoking but stopping is hard. The CESSATE study is comparing two medicines, Desmoxan and Champix, to understand how good they are at helping people to stop smoking.

Desmoxan, also called cytisine, is a medicine that comes from plant sources such as Golden Rain. It has been used in Europe for more than 50 years to help people to stop smoking. It does not contain nicotine. Desmoxan is currently not available in Australia.

Champix, also called varenicline, is currently available and widely used in Australia.

Desmoxan and Champix act similarly by reducing the reward you get from smoking. They also make withdrawal symptoms less severe.

What we don’t know about these medicines is if one is better than the other, or if they are equally as good at helping people stop smoking. This is why we are undertaking the CESSATE study.

If you are interested in the study please call 1800 290 612 or email  cessate@unsw.edu.au

If you would like to know more about the study please read our participant information sheet. This sheet will tell you more about the study, who can and cannot participate, and what it involves. A brief description is provided below.

The Study

We plan to recruit 1,266 people into the CESSATE study. All participants will be in the study for seven months and receive five telephone calls during this period. The research team will ask you some questions about the study medicine, your smoking and your health during these telephone interviews. If you agree to take part in the study, you will be randomly put (like the toss of a coin) into one of two groups:

Desmoxan group: If you are in this group you will get a 25-day supply of Desmoxan capsules (Cytisine) which is sufficient to complete the full treatment course. Please click here to read more about Desmoxan. 

Champix group: If you are in this group you will get a 12-week supply of Champix tablets (varenicline). Please click here to read more about Champix. 

You can take part in the CESSATE Study if you:

  • Are 18 years old or older
  • Are a current daily smoker
  • Are wanting to quit
  • Are willing to use either Desmoxan or Champix
  • Are able to give verbal consent
  • Have access to a telephone
  • Are willing to complete follow-ups

You cannot take part in this study if you:

  • Are pregnant or breastfeeding
  • Are currently using any other cessation medications
  • Are participating in another cessation program
  • Are hypersensitive to Desmoxan or Champix
  • Have had arrhythmia (heart rhythm disorder), heart attack, stroke or severe angina (heart pain) in the last three months
  • Have pheochromocytoma (a tumour of adrenal gland) or hyperthyroidism

If you would like to know more about the study please read our participant information sheet. This sheet will tell you more about the study, who can and cannot participate, and what it involves.  

If you are interested in the study please call 1800 290 612 or email  cessate@unsw.edu.au

Drug Type: 
Project Status: 
Current