Opioid overdose is a major public health issue associated with substantial morbidity and mortality in Australia. Indeed, nearly half the IDRS sample in 2019 reported having experienced an opioid overdose. Naloxone is an important intervention which reverses opioid overdose and has been available over-the-counter in Australia since 2016. This bulletin describes the awareness of naloxone and the take-home naloxone program in Australia, both nationally and by jurisdiction. It also explores access, use and acceptance of naloxone, and examines demographic differences for these aspects.