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Effect of Cytisine vs Varenicline on Smoking Cessation

Results from the largest trial ever undertaken for cytisine on its effectiveness compared to the most effective frontline treatment, varenicline, could lead to wider cytisine access for people who smoke. Trial findings were published in The Journal of the American Medical Association (JAMA).

Cytisine acts similarly to varenicline and reduces urges to smoke and other nicotine withdrawal symptoms, but at standard dosing (25 days) it was unknown whether it was as effective as varenicline (non-inferior) at promoting smoking cessation.

Researchers at The National Drug and Alcohol Research Centre (NDARC), UNSW Sydney have answered this question by recruiting 1452 Australian adults who smoked daily and were willing to make a quit attempt into a world-leading non-inferiority trial.

Read the full report here.

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